For Healthcare Providers
A.D. Jadczak, N. Makwana, N. Luscombe-Marsh, et al.JBI Database System Rev Implement Rep. 2018;16(3):752-775 This umbrella review aimed to determine the effectiveness of exercise interventions, alone or in combination with other interventions, in improving physical function in community-dwelling older people identified as pre-frail or frail.
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J. Apóstolo, R. Cooke, E. Bobrowicz-Campos, et al.JBI Database System Rev Implement Rep. 2018;16(1):140-232 The aim of this systematic review is to summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults. This review found mixed results regarding the effectiveness of frailty interventions. However, there is clear evidence on the usefulness of such interventions in carefully chosen evidence-based circumstances, both for frailty itself and for secondary outcomes, supporting clinical investment of resources in frailty intervention. Further research is required to reinforce current evidence and examine the impact of the initial level of frailty on the benefits of different interventions. There is also a need for economic evaluation of frailty interventions.
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M. Gutiérrez-Valencia, M. Izquierdo, M. Cesari, et al.Br J Clin Pharmacol. 2018 Mar 25. doi: 10.1111/bcp.13590. [Epub ahead of print] Frailty and polypharmacy are common in older adults. This is the first systematic review analysing the available evidence on the relationship between frailty and polypharmacy in older adults. A reduction of polypharmacy could be a cautious strategy to prevent and manage frailty. Further research is needed to confirm the possible benefits of reducing polypharmacy in the development, reversion or delay of frailty.
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G. KojimaJ Am Med Dir Assoc. 2018;19(6):480-483 The objectives is to conduct a systematic review of the literature on prospective cohort studies examining mortality risk according to frailty defined by FRAIL scale, and to perform a meta-analysis to synthesize the pooled risk estimates.
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T.E. Reeve, R. Ur, T.E. Craven, et al.J Vasc Surg. 2018;67(5):1512-1520 Frailty measures based on walking-based tests may be impractical or invalid for patients with walking impairment from symptoms or sequelae of vascular disease. We hypothesized that grip strength is associated with frailty, comorbidity, and cardiac risk among patients with vascular disease.
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B. Davies, F. García, I. Ara, et al.J Am Med Dir Assoc. 2018;19(4):282-286 Frailty and sarcopenia are distinct but related conditions. Sarcopenia is not a useful clinical biomarker of frailty, but its absence might be useful to exclude frailty.
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