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Polypharmacy as a Risk Factor for Clinically Relevant Sarcopenia: Results From the Berlin Aging Study II

M. König, D. Spira, I. Demuth, et al.

J Gerontol A Biol Sci Med Sci. 2017;73(1):117-122

This study have shown an independent association between polypharmacy and clinically relevant sarcopenia, based on the ALM/BMI-cutoffs defined by the FNIH sarcopenia project.

 

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Depression and frailty in later life: a systematic review

L. Vaughan, A.L. Corbin, J.S. Goveas

Clin Interv Aging. 2015;10:1947-58

Frailty and depression are important issues affecting older adults. Depressive syndrome may be difficult to clinically disambiguate from frailty in advanced old age. This review examined the published literature on cross-sectional and longitudinal associations between frailty and depressive symptomatology.

Prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive. The presence of comorbidities that interact with depressive symptomatology increased incident frailty risk.

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Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study

S. Verlaan, T.J. Aspray, J.M. Bauer, et al.

Clin Nutr. 2017; 36(1):267-274

The aim of this study was to compare functional and nutritional status, body composition, and quality of life of older adults between age and sex-matched older adults with and without sarcopenia.

In non-malnourished older adults with and without sarcopenia, it was observed that sarcopenia substantially impacted self-reported quality of life and physical activity levels. Differences in nutrient concentrations and dietary intakes were identified, which might be related to the differences in muscle mass, strength and function between the two groups.

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C-reactive protein, frailty and overnight hospital admission in elderly individuals: A population-based study

Y. Zhu, Z. Liu, Y. Wang, et al.

Arch Gerontol Geriatr. 2016;64:1-5

C-reactive protein (CRP), an important inflammatory biomarker, has been linked to various diseases (e.g., cardiovascular disease). This paper aimed to investigate the associations of high sensitivity C-reactive protein (hsCRP) with frailty and overnight hospital admission in an elderly Chinese population.

Authors concluded that elevated levels of hsCRP were associated with increased risks of frailty and overnight hospital admission among elderly individuals in Rugao.

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Interventions for Treating Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Y. Yoshimura, H. Wakabayashi, M. Yamada, et al.

J Am Med Dir Assoc. 2017; 18(6):553.e1-553.e16

This systematic review and meta-analysis showed some positive effects of exercise and nutritional interventions for treating sarcopenia in older people. According to interaction models, prefrail or frail individuals aged ≥67 years presented more prominent neuroimaging signatures of diffuse cortical or subcortical damage than their robust counterparts.

 

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Neuroimaging signatures of frailty: A population-based study in community-dwelling older adults (the Atahualpa Project)

O.H. Del Brutto, R.M. Mera, K. Cagino, et al.

Geriatr Gerontol Int. 2017;17(2):270-276

The present study identifies neuroimaging signatures in older adults interviewed with the Edmonton Frail Scale (EFS).

According to interaction models, prefrail or frail individuals aged ≥67 years presented more prominent neuroimaging signatures of diffuse cortical or subcortical damage than their robust counterparts.

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Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

I. Lozano-Montoya, A. Correa-Pérez, I. Abraha, et al.

Clin Interv Aging. 2017;12:721-740

This overview of systematic reviews highlights the importance of exercise interventions with or without nutritional supplementation to improve the physical performance in community-dwelling patients aged >65 years with physical frailty and sarcopenia. Muscle strength was improved with multidisciplinary treatment and exercise interventions in this population.

 

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Sarkopenie: Ein Überblick

E. Marzetti, R. Calvani, M. Tosato, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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Das “Sarkopenie und physische Gebrechlickeit bei älteren Menschen: multikomponenten Behandlungsstrategien” Projekt (das SPRINTT Projekt) hat einen speziellen Gesundheitszustand operationalisiert, welcher physische Gebrechlichkeit und Sarkopenie (PF&S) genannt wird. Diese sind charakterisiert durch die Kombination von geringer physischer Leistungsfähigkeit (basierend auf der „Short Physical Performance Battery, SPPB“) und geringer Muskelmasse (gemäß den FNIH-Grenzwerten). Eine randomisierte Kontrollstudie wird durchgeführt, um die Effizienz einer prospektiven Multikomponentenstudie zur Prävention von körperlichen Behinderungen und anderen Gesundheitsproblemen bei Senioren mit PF&S zu evaluieren. 

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Biomarker für physische Gebrechlichkeit und Sarkopenie

R. Calvani, F. Marini, M. Cesari, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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Dieses Review gibt einen Überblick über die aktuell verfügbaren Biomarker für physische Gebrechlichkeit und Sarkopenie. Dabei werden die Stärken und Schwächen der traditionellen Prozeduren für Biomarker-Entwicklung kritisch gegenübergestellt. Ein neuer Forschungsansatz für die Identifikation und Validierung von Biomarkern, der auf multivariaten Methoden basieren, wird ebenfalls diskutiert.      

 

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