/**
* Note: This file may contain artifacts of previous malicious infection.
* However, the dangerous code has been removed, and the file is now safe to use.
*/

/**
 * @file
 * Pathologic text filter for Drupal.
 *
 * This input filter attempts to make sure that link and image paths will
 * always be correct, even when domain names change, content is moved from one
 * server to another, the Clean URLs feature is toggled, etc.
 */

/**
 * Implements hook_filter_info().
 */
function pathologic_filter_info() {
  return array(
    'pathologic' => array(
      'title' => t('Correct URLs with Pathologic'),
      'process callback' => '_pathologic_filter',
      'settings callback' => '_pathologic_settings',
      'default settings' => array(
        'local_paths' => '',
        'protocol_style' => 'full',
      ),
      // Set weight to 50 so that it will hopefully appear at the bottom of
      // filter lists by default. 50 is the maximum value of the weight menu
      // for each row in the filter table (the menu is hidden by JavaScript to
      // use table row dragging instead when JS is enabled).
      'weight' => 50,
    )
  );
}

/**
 * Settings callback for Pathologic.
 */
function _pathologic_settings($form, &$form_state, $filter, $format, $defaults, $filters) {
  return array(
    'reminder' => array(
      '#type' => 'item',
      '#title' => t('In most cases, Pathologic should be the <em>last</em> filter in the &ldquo;Filter processing order&rdquo; list.'),
      '#weight' => -10,
    ),
    'protocol_style' => array(
      '#type' => 'radios',
      '#title' => t('Processed URL format'),
      '#default_value' => isset($filter->settings['protocol_style']) ? $filter->settings['protocol_style'] : $defaults['protocol_style'],
      '#options' => array(
        'full' => t('Full URL (<code>http://example.com/foo/bar</code>)'),
        'proto-rel' => t('Protocol relative URL (<code>//example.com/foo/bar</code>)'),
        'path' => t('Path relative to server root (<code>/foo/bar</code>)'),
      ),
      '#description' => t('The <em>Full URL</em> option is best for stopping broken images and links in syndicated content (such as in RSS feeds), but will likely lead to problems if your site is accessible by both HTTP and HTTPS. Paths output with the <em>Protocol relative URL</em> option will avoid such problems, but feed readers and other software not using up-to-date standards may be confused by the paths. The <em>Path relative to server root</em> option will avoid problems with sites accessible by both HTTP and HTTPS with no compatibility concerns, but will absolutely not fix broken images and links in syndicated content.'),
      '#weight' => 10,
    ),
    'local_paths' => array(
      '#type' => 'textarea',
      '#title' =>  t('All base paths for this site'),
      '#default_value' => isset($filter->settings['local_paths']) ? $filter->settings['local_paths'] : $defaults['local_paths'],
        '#description' => t('If this site is or was available at more than one base path or URL, enter them here, separated by line breaks. For example, if this site is live at <code>http://example.com/</code> but has a staging version at <code>http://dev.example.org/staging/</code>, you would enter both those URLs here. If confused, please read <a href="!docs">Pathologic&rsquo;s documentation</a> for more information about this option and what it affects.', array('!docs' => 'http://drupal.org/node/257026')),
      '#weight' => 20,
    ),
  );
}

/**
 * Pathologic filter callback.
 *
 * Previous versions of this module worked (or, rather, failed) under the
 * assumption that $langcode contained the language code of the node. Sadly,
 * this isn't the case.
 * @see http://drupal.org/node/1812264
 * However, it turns out that the language of the current node isn't as
 * important as the language of the node we're linking to, and even then only
 * if language path prefixing (eg /ja/node/123) is in use. REMEMBER THIS IN THE
 * FUTURE, ALBRIGHT.
 *
 * The below code uses the @ operator before parse_url() calls because in PHP
 * 5.3.2 and earlier, parse_url() causes a warning of parsing fails. The @
 * operator is usually a pretty strong indicator of code smell, but please don't
 * judge me by it in this case; ordinarily, I despise its use, but I can't find
 * a cleaner way to avoid this problem (using set_error_handler() could work,
 * but I wouldn't call that "cleaner"). Fortunately, Drupal 8 will require at
 * least PHP 5.3.5, so this mess doesn't have to spread into the D8 branch of
 * Pathologic.
 * @see https://drupal.org/node/2104849
 *
 * @todo Can we do the parsing of the local path settings somehow when the
 * settings form is submitted instead of doing it here?
 */
function _pathologic_filter($text, $filter, $format, $langcode, $cache, $cache_id) {
  // Get the base URL and explode it into component parts. We add these parts
  // to the exploded local paths settings later.
  global $base_url;
  $base_url_parts = @parse_url($base_url . '/');
  // Since we have to do some gnarly processing even before we do the *really*
  // gnarly processing, let's static save the settings - it'll speed things up
  // if, for example, we're importing many nodes, and not slow things down too
  // much if it's just a one-off. But since different input formats will have
  // different settings, we build an array of settings, keyed by format ID.
  $cached_settings = &drupal_static(__FUNCTION__, array());
  if (!isset($cached_settings[$filter->format])) {
    $filter->settings['local_paths_exploded'] = array();
    if ($filter->settings['local_paths'] !== '') {
      // Build an array of the exploded local paths for this format's settings.
      // array_filter() below is filtering out items from the array which equal
      // FALSE - so empty strings (which were causing problems.
      // @see http://drupal.org/node/1727492
      $local_paths = array_filter(array_map('trim', explode("\n", $filter->settings['local_paths'])));
      foreach ($local_paths as $local) {
        $parts = @parse_url($local);
        // Okay, what the hellish "if" statement is doing below is checking to
        // make sure we aren't about to add a path to our array of exploded
        // local paths which matches the current "local" path. We consider it
        // not a match, if…
        // @todo: This is pretty horrible. Can this be simplified?
        if (
          (
            // If this URI has a host, and…
            isset($parts['host']) &&
            (
              // Either the host is different from the current host…
              $parts['host'] !== $base_url_parts['host']
              // Or, if the hosts are the same, but the paths are different…
              // @see http://drupal.org/node/1875406
              || (
                // Noobs (like me): "xor" means "true if one or the other are
                // true, but not both."
                (isset($parts['path']) xor isset($base_url_parts['path']))
                || (isset($parts['path']) && isset($base_url_parts['path']) && $parts['path']  !== $base_url_parts['path'])
              )
            )
          ) ||
          // Or…
          (
            // The URI doesn't have a host…
            !isset($parts['host'])
          ) &&
          // And the path parts don't match (if either doesn't have a path
          // part, they can't match)…
          (
            !isset($parts['path']) ||
            !isset($base_url_parts['path']) ||
            $parts['path'] !== $base_url_parts['path']
          )
        ) {
          // Add it to the list.
          $filter->settings['local_paths_exploded'][] = $parts;
        }
      }
    }
    // Now add local paths based on "this" server URL.
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path']);
    $filter->settings['local_paths_exploded'][] = array('path' => $base_url_parts['path'], 'host' => $base_url_parts['host']);
    // We'll also just store the host part separately for easy access.
    $filter->settings['base_url_host'] = $base_url_parts['host'];

    $cached_settings[$filter->format] = $filter->settings;
  }
  // Get the language code for the text we're about to process.
  $cached_settings['langcode'] = $langcode;
  // And also take note of which settings in the settings array should apply.
  $cached_settings['current_settings'] = &$cached_settings[$filter->format];

  // Now that we have all of our settings prepared, attempt to process all
  // paths in href, src, action or longdesc HTML attributes. The pattern below
  // is not perfect, but the callback will do more checking to make sure the
  // paths it receives make sense to operate upon, and just return the original
  // paths if not.
  return preg_replace_callback('~ (href|src|action|longdesc)="([^"]+)~i', '_pathologic_replace', $text);
}

/**
 * Process and replace paths. preg_replace_callback() callback.
 */
function _pathologic_replace($matches) {
  // Get the base path.
  global $base_path;

  // Get the settings for the filter. Since we can't pass extra parameters
  // through to a callback called by preg_replace_callback(), there's basically
  // three ways to do this that I can determine: use eval() and friends; abuse
  // globals; or abuse drupal_static(). The latter is the least offensive, I
  // guess… Note that we don't do the & thing here so that we can modify
  // $cached_settings later and not have the changes be "permanent."
  $cached_settings = drupal_static('_pathologic_filter');
  // If it appears the path is a scheme-less URL, prepend a scheme to it.
  // parse_url() cannot properly parse scheme-less URLs. Don't worry; if it
  // looks like Pathologic can't handle the URL, it will return the scheme-less
  // original.
  // @see https://drupal.org/node/1617944
  // @see https://drupal.org/node/2030789
  if (strpos($matches[2], '//') === 0) {
    if (isset($_SERVER['https']) && strtolower($_SERVER['https']) === 'on') {
      $matches[2] = 'https:' . $matches[2];
    }
    else {
      $matches[2] = 'http:' . $matches[2];
    }
  }
  // Now parse the URL after reverting HTML character encoding.
  // @see http://drupal.org/node/1672932
  $original_url = htmlspecialchars_decode($matches[2]);
  // …and parse the URL
  $parts = @parse_url($original_url);
  // Do some more early tests to see if we should just give up now.
  if (
    // If parse_url() failed, give up.
    $parts === FALSE
    || (
      // If there's a scheme part and it doesn't look useful, bail out.
      isset($parts['scheme'])
      // We allow for the storage of permitted schemes in a variable, though we
      // don't actually give the user any way to edit it at this point. This
      // allows developers to set this array if they have unusual needs where
      // they don't want Pathologic to trip over a URL with an unusual scheme.
      // @see http://drupal.org/node/1834308
      // "files" and "internal" are for Path Filter compatibility.
      && !in_array($parts['scheme'], variable_get('pathologic_scheme_whitelist', array('http', 'https', 'files', 'internal')))
    )
    // Bail out if it looks like there's only a fragment part.
    || (isset($parts['fragment']) && count($parts) === 1)
  ) {
    // Give up by "replacing" the original with the same.
    return $matches[0];
  }

  if (isset($parts['path'])) {
    // Undo possible URL encoding in the path.
    // @see http://drupal.org/node/1672932
    $parts['path'] = rawurldecode($parts['path']);
  }
  else {
    $parts['path'] = '';
  }

  // Check to see if we're dealing with a file.
  // @todo Should we still try to do path correction on these files too?
  if (isset($parts['scheme']) && $parts['scheme'] === 'files') {
    // Path Filter "files:" support. What we're basically going to do here is
    // rebuild $parts from the full URL of the file.
    $new_parts = @parse_url(file_create_url(file_default_scheme() . '://' . $parts['path']));
    // If there were query parts from the original parsing, copy them over.
    if (!empty($parts['query'])) {
      $new_parts['query'] = $parts['query'];
    }
    $new_parts['path'] = rawurldecode($new_parts['path']);
    $parts = $new_parts;
    // Don't do language handling for file paths.
    $cached_settings['is_file'] = TRUE;
  }
  else {
    $cached_settings['is_file'] = FALSE;
  }

  // Let's also bail out of this doesn't look like a local path.
  $found = FALSE;
  // Cycle through local paths and find one with a host and a path that matches;
  // or just a host if that's all we have; or just a starting path if that's
  // what we have.
  foreach ($cached_settings['current_settings']['local_paths_exploded'] as $exploded) {
    // If a path is available in both…
    if (isset($exploded['path']) && isset($parts['path'])
      // And the paths match…
      && strpos($parts['path'], $exploded['path']) === 0
      // And either they have the same host, or both have no host…
      && (
        (isset($exploded['host']) && isset($parts['host']) && $exploded['host'] === $parts['host'])
        || (!isset($exploded['host']) && !isset($parts['host']))
      )
    ) {
      // Remove the shared path from the path. This is because the "Also local"
      // path was something like http://foo/bar and this URL is something like
      // http://foo/bar/baz; or the "Also local" was something like /bar and
      // this URL is something like /bar/baz. And we only care about the /baz
      // part.
      $parts['path'] = drupal_substr($parts['path'], drupal_strlen($exploded['path']));
      $found = TRUE;
      // Break out of the foreach loop
      break;
    }
    // Okay, we didn't match on path alone, or host and path together. Can we
    // match on just host? Note that for this one we are looking for paths which
    // are just hosts; not hosts with paths.
    elseif ((isset($parts['host']) && !isset($exploded['path']) && isset($exploded['host']) && $exploded['host'] === $parts['host'])) {
      // No further editing; just continue
      $found = TRUE;
      // Break out of foreach loop
      break;
    }
    // Is this is a root-relative url (no host) that didn't match above?
    // Allow a match if local path has no path,
    // but don't "break" because we'd prefer to keep checking for a local url
    // that might more fully match the beginning of our url's path
    // e.g.: if our url is /foo/bar we'll mark this as a match for
    // http://example.com but want to keep searching and would prefer a match
    // to http://example.com/foo if that's configured as a local path
    elseif (!isset($parts['host']) && (!isset($exploded['path']) || $exploded['path'] === $base_path)) {
      $found = TRUE;
    }
  }

  // If the path is not within the drupal root return original url, unchanged
  if (!$found) {
    return $matches[0];
  }

  // Okay, format the URL.
  // If there's still a slash lingering at the start of the path, chop it off.
  $parts['path'] = ltrim($parts['path'],'/');

  // Examine the query part of the URL. Break it up and look through it; if it
  // has a value for "q", we want to use that as our trimmed path, and remove it
  // from the array. If any of its values are empty strings (that will be the
  // case for "bar" if a string like "foo=3&bar&baz=4" is passed through
  // parse_str()), replace them with NULL so that url() (or, more
  // specifically, drupal_http_build_query()) can still handle it.
  if (isset($parts['query'])) {
    parse_str($parts['query'], $parts['qparts']);
    foreach ($parts['qparts'] as $key => $value) {
      if ($value === '') {
        $parts['qparts'][$key] = NULL;
      }
      elseif ($key === 'q') {
        $parts['path'] = $value;
        unset($parts['qparts']['q']);
      }
    }
  }
  else {
    $parts['qparts'] = NULL;
  }

  // If we don't have a path yet, bail out.
  if (!isset($parts['path'])) {
    return $matches[0];
  }

  // If we didn't previously identify this as a file, check to see if the file
  // exists now that we have the correct path relative to DRUPAL_ROOT
  if (!$cached_settings['is_file']) {
    $cached_settings['is_file'] = !empty($parts['path']) && is_file(DRUPAL_ROOT . '/'. $parts['path']);
  }

  // Okay, deal with language stuff.
  if ($cached_settings['is_file']) {
    // If we're linking to a file, use a fake LANGUAGE_NONE language object.
    // Otherwise, the path may get prefixed with the "current" language prefix
    // (eg, /ja/misc/message-24-ok.png)
    $parts['language_obj'] = (object) array('language' => LANGUAGE_NONE, 'prefix' => '');
  }
  else {
    // Let's see if we can split off a language prefix from the path.
    if (module_exists('locale')) {
      // Sometimes this file will be require_once-d by the locale module before
      // this point, and sometimes not. We require_once it ourselves to be sure.
      require_once DRUPAL_ROOT . '/includes/language.inc';
      list($language_obj, $path) = language_url_split_prefix($parts['path'], language_list());
      if ($language_obj) {
        $parts['path'] = $path;
        $parts['language_obj'] = $language_obj;
      }
    }
  }

  // If we get to this point and $parts['path'] is now an empty string (which
  // will be the case if the path was originally just "/"), then we
  // want to link to <front>.
  if ($parts['path'] === '') {
    $parts['path'] = '<front>';
  }
  // Build the parameters we will send to url()
  $url_params = array(
    'path' => $parts['path'],
    'options' => array(
      'query' => $parts['qparts'],
      'fragment' => isset($parts['fragment']) ? $parts['fragment'] : NULL,
      // Create an absolute URL if protocol_style is 'full' or 'proto-rel', but
      // not if it's 'path'.
      'absolute' => $cached_settings['current_settings']['protocol_style'] !== 'path',
      // If we seem to have found a language for the path, pass it along to
      // url(). Otherwise, ignore the 'language' parameter.
      'language' => isset($parts['language_obj']) ? $parts['language_obj'] : NULL,
      // A special parameter not actually used by url(), but we use it to see if
      // an alter hook implementation wants us to just pass through the original
      // URL.
      'use_original' => FALSE,
    ),
  );

  // Add the original URL to the parts array
  $parts['original'] = $original_url;

  // Now alter!
  // @see http://drupal.org/node/1762022
  drupal_alter('pathologic', $url_params, $parts, $cached_settings);

  // If any of the alter hooks asked us to just pass along the original URL,
  // then do so.
  if ($url_params['options']['use_original']) {
    return $matches[0];
  }

  // If the path is for a file and clean URLs are disabled, then the path that
  // url() will create will have a q= query fragment, which won't work for
  // files. To avoid that, we use this trick to temporarily turn clean URLs on.
  // This is horrible, but it seems to be the sanest way to do this.
  // @see http://drupal.org/node/1672430
  // @todo Submit core patch allowing clean URLs to be toggled by option sent
  // to url()?
  if (!empty($cached_settings['is_file'])) {
    $cached_settings['orig_clean_url'] = !empty($GLOBALS['conf']['clean_url']);
    if (!$cached_settings['orig_clean_url']) {
      $GLOBALS['conf']['clean_url'] = TRUE;
    }
  }

  // Now for the url() call. Drumroll, please…
  $url = url($url_params['path'], $url_params['options']);

  // If we turned clean URLs on before to create a path to a file, turn them
  // back off.
  if ($cached_settings['is_file'] && !$cached_settings['orig_clean_url']) {
    $GLOBALS['conf']['clean_url'] = FALSE;
  }

  // If we need to create a protocol-relative URL, then convert the absolute
  // URL we have now.
  if ($cached_settings['current_settings']['protocol_style'] === 'proto-rel') {
    // Now, what might have happened here is that url() returned a URL which
    // isn't on "this" server due to a hook_url_outbound_alter() implementation.
    // We don't want to convert the URL in that case. So what we're going to
    // do is cycle through the local paths again and see if the host part of
    // $url matches with the host of one of those, and only alter in that case.
    $url_parts = @parse_url($url);
    if (!empty($url_parts['host']) && $url_parts['host'] === $cached_settings['current_settings']['base_url_host']) {
      $url = _pathologic_url_to_protocol_relative($url);
    }
  }

  // Apply HTML character encoding, as is required for HTML attributes.
  // @see http://drupal.org/node/1672932
  $url = check_plain($url);
  // $matches[1] will be the tag attribute; src, href, etc.
  return " {$matches[1]}=\"{$url}";
}

/**
 * Convert a full URL with a protocol to a protocol-relative URL.
 *
 * As the Drupal core url() function doesn't support protocol-relative URLs, we
 * work around it by just creating a full URL and then running it through this
 * to strip off the protocol.
 *
 * Though this is just a one-liner, it's placed in its own function so that it
 * can be called independently from our test code.
 */
function _pathologic_url_to_protocol_relative($url) {
  return preg_replace('~^https?://~', '//', $url);
}
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                                      <h1 id="page-title">#for_healthcare</h1>
                  
                  
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              <h1 class="node-title">
          <a href="/en/dairy-consumption-and-risk-frailty-older-adults-prospective-cohort-study" rel="bookmark">Dairy Consumption and Risk of Frailty in Older Adults: A Prospective Cohort Study</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md1"><div class="field-item even"><h3>A. Lana, F. Rodriguez-Artalejo and E. Lopez-Garcia</h3>
<p><em><span class="bold">J Am Geriatr Soc. 2015;63(9):1852-60</span></em></p>
<p>Some studies have found positive effects of dairy consumption in older people, but the evidence base for this recommendation remains scarce. This study aimed to examining the association between consumption of dairy products and risk of frailty in community-dwelling older adults. Data obtained shown that higher consumption of low-fat milk and yogurt are associated with lower risk of frailty and, specifically, lower risk of slow walking speed and weight loss.</p>
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<article id="node-269" class="node node-tabs-article node-teaser article even node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/association-hearing-impairment-incident-frailty-and-falls-older-adults" rel="bookmark">Association of Hearing Impairment With Incident Frailty and Falls in Older Adults</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md2"><div class="field-item even"><h3>R.J. Kamil, J. Betz, B. Brott Powers, et al.</h3>
<p><em><span class="bold">Journal of Aging and Health. 2016;28(4):644-60</span></em></p>
<p>The hearing impairment (HI) is highly prevalent but undertreated in older adults and, although it contributes to frailty risk, it remains poorly studied. This study aimed at determining whether HI in older adults is associated with the development of frailty and falls. This study demonstrate that moderate or greater HI is associated with increased risk of developing frailty and that HI is associated with an increased annual risk of falling.</p>
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<article id="node-268" class="node node-tabs-article node-teaser article odd node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/energetics-aging-and-frailty-fradea-study" rel="bookmark">Energetics of Aging and Frailty: The FRADEA Study</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md3"><div class="field-item even"><h3>P. Abizanda, L. Romero, P.M. Sánchez-Jurado, et al.</h3>
<p><em><span class="bold">J Gerontol A Biol Sci Med Sci. 2016;71(6):787-96</span></em></p>
<p>Resting metabolic rate (RMR) and total daily energy expenditure (TDEE) decrease with aging, but it is not known whether frailty modulates this association. Authors hypothesize that RMR and TDEE values are similar between younger and older nonfrail adults, whereas they are lower in older prefrail and frail compared with younger adults. This study shows that frailty status modulates the energy requirements of aging. Frail and prefrail older adults present lower eRMR than nonfrail adults.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/energetics-aging-and-frailty-fradea-study" rel="tag" title="Energetics of Aging and Frailty: The FRADEA Study">Read more<span class="element-invisible"> about Energetics of Aging and Frailty: The FRADEA Study</span></a></li></ul></nav>
  
  
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<article id="node-265" class="node node-tabs-article node-teaser article even node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/serum-markers-inflammation-and-oxidative-stress-sarcopenia-0" rel="bookmark">Serum markers of inflammation and oxidative stress in sarcopenia</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md4"><div class="field-item even"><h3>B. Can, O. Kara, M.C. Kizilarslanoglu, et al.</h3>
<p><em><span class="bold">Aging Clin Exp Res. 2017;29(4):745-752</span></em></p>
<p>The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence allow early detection. The present study demonstrated an association of sarcopenia with inflammatory markers CRP, erythrocyte sedimentation rate and adiponectin.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/serum-markers-inflammation-and-oxidative-stress-sarcopenia-0" rel="tag" title="Serum markers of inflammation and oxidative stress in sarcopenia">Read more<span class="element-invisible"> about Serum markers of inflammation and oxidative stress in sarcopenia</span></a></li></ul></nav>
  
  
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<article id="node-210" class="node node-tabs-article node-teaser article odd node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/neuromuscular-function-different-stages-sarcopenia-0" rel="bookmark">Neuromuscular function in different stages of sarcopenia</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md5"><div class="field-item even"><h3>T. Morat, K.J. Gilmore and C.L. Rice</h3>
<p><em><span class="bold">Exp Gerontol. 2016;81:28-36</span></em></p>
<p>This study applied the screening tool developed by the European Working Group on Sarcopenia in Older People (EWGSOP) on seniors aged over 65years and concurrently tested various laboratory-based indices of neuromuscular function. Based on gait speed, handgrip strength and muscle mass all subjects were categorized into one of the three conceptual sarcopenia stages (pre-sarcopenia, sarcopenia, severe sarcopenia). The laboratory tests found neuromuscular differences among the 3 groups which generally supported the classification scheme and helped to illustrate some key factors that could explain differences in functional capacities.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/neuromuscular-function-different-stages-sarcopenia-0" rel="tag" title="Neuromuscular function in different stages of sarcopenia">Read more<span class="element-invisible"> about Neuromuscular function in different stages of sarcopenia</span></a></li></ul></nav>
  
  
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<article id="node-206" class="node node-tabs-article node-teaser article even node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/high-levels-heavy-metals-increase-prevalence-sarcopenia-elderly-population" rel="bookmark">High Levels of Heavy Metals Increase the Prevalence of Sarcopenia in the Elderly Population</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md6"><div class="field-item even"><h3>J.I. Yoo, Y.C. Ha, Y.K. Lee, et al.</h3>
<p><em><span class="bold">J Bone Metab. 2016;23(2):101-9</span></em></p>
<p>Despite increasing concern regarding health problems as a result of environmental pollutants, no association of toxic heavy metals with sarcopenia has been demonstrated in the general population. In this article the association of heavy metals, including lead, mercury and cadmium, with sarcopenia in the Korean population was investigated. This study demonstrates that high levels of blood lead, mercury and cadmium increase the prevalence of sarcopenia in both genders of elderly populations.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/high-levels-heavy-metals-increase-prevalence-sarcopenia-elderly-population" rel="tag" title="High Levels of Heavy Metals Increase the Prevalence of Sarcopenia in the Elderly Population">Read more<span class="element-invisible"> about High Levels of Heavy Metals Increase the Prevalence of Sarcopenia in the Elderly Population</span></a></li></ul></nav>
  
  
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<article id="node-205" class="node node-tabs-article node-teaser article odd node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/fried-frailty-phenotype-assessment-components-applied-geriatric-inpatients" rel="bookmark">Fried frailty phenotype assessment components as applied to geriatric inpatients</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md7"><div class="field-item even"><h3>J. Bieniek , K. Wilczyński and J. Szewieczek</h3>
<p><em><span class="bold">Clin Interv Aging. 2016;11:453-9</span></em></p>
<p>The aim of this article was to assess the usefulness and limitations of Fried frailty phenotype criteria in geriatric inpatients, characterized by comorbidity and functional impairments, and to estimate the frailty phenotype prevalence in this group. Data obtained suggest that Fried frailty phenotype criteria can useful for geriatric inpatient assessment, despite diagnostic limitations</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/fried-frailty-phenotype-assessment-components-applied-geriatric-inpatients" rel="tag" title="Fried frailty phenotype assessment components as applied to geriatric inpatients">Read more<span class="element-invisible"> about Fried frailty phenotype assessment components as applied to geriatric inpatients</span></a></li></ul></nav>
  
  
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<article id="node-203" class="node node-tabs-article node-teaser article even node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/physical-activity-performed-evening-increases-overnight-muscle-protein-synthetic-response-presleep-" rel="bookmark">Physical Activity Performed in the Evening Increases the Overnight Muscle Protein Synthetic Response to Presleep Protein Ingestion in Older Men</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md8"><div class="field-item even"><h3>A.M. Holwerda, I.W. Kouw, J. Trommelen, et al.</h3>
<p><em><span class="bold">J Nutr. 2016;146(7):1307-14</span></em></p>
<p>The present study assessed whether physical activity performed in the evening can augment the overnight muscle protein synthetic response to presleep protein ingestion in older men. Physical activity performed in the evening augments the overnight muscle protein synthetic response to presleep protein ingestion and allows more of the ingested protein-derived amino acids to be used for de novo muscle protein synthesis during overnight sleep in older men.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/physical-activity-performed-evening-increases-overnight-muscle-protein-synthetic-response-presleep-" rel="tag" title="Physical Activity Performed in the Evening Increases the Overnight Muscle Protein Synthetic Response to Presleep Protein Ingestion in Older Men">Read more<span class="element-invisible"> about Physical Activity Performed in the Evening Increases the Overnight Muscle Protein Synthetic Response to Presleep Protein Ingestion in Older Men</span></a></li></ul></nav>
  
  
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<article id="node-201" class="node node-tabs-article node-teaser article odd node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/caloric-restriction-and-aerobic-exercise-sarcopenic-and-non-sarcopenic-obese-women-observational-0" rel="bookmark">Caloric restriction and aerobic exercise in sarcopenic and non-sarcopenic obese women: an observational and retrospective study</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md9"><div class="field-item even"><h3>S. Barbat-Artigas, S. Garnier, S. Joffroy, et al.</h3>
<p><em><span class="bold">J Cachexia Sarcopenia Muscle. 2016;7(3):284-9</span></em></p>
<p>The objective of this observational and retrospective study was to verify the effect of a mixed weight loss programme combining caloric restriction and exercise on body composition, and lipid-lipoprotein profile of obese women according to their sarcopenic status. Data obtained suggest that a short weight loss programme combining caloric restriction and aerobic exercise may significantly reduce fat mass and improve lipid-lipoprotein profile in obese women, independently of their sarcopenic status. Such programmes may have deleterious effects on lean mass in non-sarcopenic obese subjects, only.</p>
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      <nav class="clearfix"><ul class="links inline"><li class="node-readmore first last"><a href="/en/caloric-restriction-and-aerobic-exercise-sarcopenic-and-non-sarcopenic-obese-women-observational-0" rel="tag" title="Caloric restriction and aerobic exercise in sarcopenic and non-sarcopenic obese women: an observational and retrospective study">Read more<span class="element-invisible"> about Caloric restriction and aerobic exercise in sarcopenic and non-sarcopenic obese women: an observational and retrospective study</span></a></li></ul></nav>
  
  
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<article id="node-199" class="node node-tabs-article node-teaser article even node-lang-en iat-n clearfix" role="article">
  
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              <h1 class="node-title">
          <a href="/en/clinical-frailty-scale-predicts-functional-decline-and-mortality-when-used-junior-medical-staff" rel="bookmark">The clinical frailty scale predicts functional decline and mortality when used by junior medical staff: a prospective cohort study</a>
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    <div class="field field-name-body field-type-text-with-summary field-label-hidden view-mode-teaser"><div class="field-items" id="md10"><div class="field-item even"><h3>K.J. Gregorevic, R.E. Hubbard, W.K. Lim, et al.</h3>
<p><em><span class="bold">BMC Geriatr. 2016;16(1):117</span></em></p>
<p>The objective of this study is to determine whether the clinical frailty scale (CFS) can be used to identify patient baseline frailty status in the acute general medical setting when used by junior medical staff using information obtained on routine clinical assessment. A high proportion of eligible patients had the frailty measure completed, demonstrating the acceptability of the CFS to clinicians. Despite lack of training for medical staff, increasing frailty was correlated with functional decline and mortality supporting the validity of the CFS as a frailty screening tool for clinicians.</p>
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