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Biomarkers for physical frailty and sarcopenia

R. Calvani, F. Marini, M. Cesari, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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This review provides an overview of currently available biological markers for PF and sarcopenia, as well as a critical appraisal of strengths and weaknesses of traditional procedures for biomarker development in the field. A novel approach for biomarker identification and validation, based on multivariate methodologies, is also discussed.

 

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The “Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people

R. Bernabei, L. Mariotti, P. Bordes, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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 The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project has been designed to produce significant advancements in the management of older persons with PF&S.

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SPRINTT and the involvement of stakeholders: strategy and structure

R. Le Lain, C. Ignaszewski, I. Klingmann, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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The present article describes the SPRINTT workpackage activities aimed at engaging the scientific discussion on the physical frailty and sarcopenia with the EMA as one of its interlocutor acknowledging the need to collaborate on this topic to foster a productive dialogue.

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Sarcopenia: an overview

E. Marzetti, R. Calvani, M. Tosato, et al.

Aging Clin Exp Res Epub 2017 Feb 10

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The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” project (the SPRINTT project) has operationalized a specific condition, named physical frailty and sarcopenia (PF&S), characterized by the combination of low physical performance (based on the Short Physical Performance Battery) and low muscle mass (according to the FNIH cut-points). A randomized controlled trial will be conducted to evaluate the efficacy of a multi-component intervention for preventing mobility disability and other adverse health outcomes in older adults with PF&S.

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Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

I. Lozano-Montoya, A. Correa-Pérez, I. Abraha, et al.

Clin Interv Aging. 2017;12:721-740

This overview of systematic reviews highlights the importance of exercise interventions with or without nutritional supplementation to improve the physical performance in community-dwelling patients aged >65 years with physical frailty and sarcopenia. Muscle strength was improved with multidisciplinary treatment and exercise interventions in this population.

 

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Neuroimaging signatures of frailty: A population-based study in community-dwelling older adults (the Atahualpa Project)

O.H. Del Brutto, R.M. Mera, K. Cagino, et al.

Geriatr Gerontol Int. 2017 ;17(2):270-276

The present study identifies neuroimaging signatures in older adults interviewed with the Edmonton Frail Scale (EFS).

According to interaction models, prefrail or frail individuals aged ≥67 years presented more prominent neuroimaging signatures of diffuse cortical or subcortical damage than their robust counterparts.

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Interventions for Treating Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Y. Yoshimura, H. Wakabayashi, M. Yamada, et al.

J Am Med Dir Assoc. 2017; 18(6):553.e1-553.e16

This systematic review and meta-analysis showed some positive effects of exercise and nutritional interventions for treating sarcopenia in older people.According to interaction models, prefrail or frail individuals aged ≥67 years presented more prominent neuroimaging signatures of diffuse cortical or subcortical damage than their robust counterparts.

 

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